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This is a finding aid. It is a description of archival material held in the Wilson Library at the University of North Carolina at Chapel Hill. Unless otherwise noted, the materials described below are physically available in our reading room, and not digitally available through the World Wide Web. See the Duplication Policy section for more information.
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Collection Overview
| Size | 18 feet of linear shelf space (approximately 1350 items) |
| Abstract | Oliver Smithies (1925-2017) was a British-born American geneticist and biochemist who won the 2007 Nobel Prize for Physiology or Medicine for developing gene targeting, a technology used to create animal models of human diseases in mice. This collection contains Smithies's class notes and tutorial essays written during his time as a student at the University of Oxford, as well as research notes, student papers, and laboratory notebooks compiled by Smithies throughout his career. Of particular note are some of Smithies's research notes related to the discoveries that helped earn him the Nobel Prize. |
| Creator | Smithies, Oliver |
| Curatorial Unit | University of North Carolina at Chapel Hill. Library. University Archives. |
| Language | English |
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Information For Users
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Processing Information
Processed by: Jennifer Coggins, April 2017
Encoded by: Laura Smith, April 2017
Finding aid updated because of addition by Clare Carlson and Laura Smith, August 2019
Since August 2017, we have added ethnic and racial identities for individuals and families represented in collections. To determine identity, we rely on self-identification; other information supplied to the repository by collection creators or sources; public records, press accounts, and secondary sources; and contextual information in the collection materials. Omissions of ethnic and racial identities in finding aids created or updated after August 2017 are an indication of insufficient information to make an educated guess or an individual's preference for identity information to be excluded from description. When we have misidentified, please let us know at wilsonlibrary@unc.edu.
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Subject Headings
The following terms from Library of Congress Subject Headings suggest topics, persons, geography, etc. interspersed through the entire collection; the terms do not usually represent discrete and easily identifiable portions of the collection--such as folders or items.
Clicking on a subject heading below will take you into the University Library's online catalog.
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Biographical Information
Oliver Smithies (1925-2017) was a British-born American scientist who, with Mario R. Capecchi and Sir Martin J. Evans, won the 2007 Nobel Prize for Physiology or Medicine for developing gene targeting, a technology used to create animal models of human diseases in mice.
In 1951 Smithies earned both a master’s degree and a doctorate in biochemistry from the University of Oxford and later moved to the United States, where he studied at the University of Wisconsin. The following year he joined the Connaught Medical Research Laboratory at the University of Toronto, where he developed the starch gel electrophoresis technique, an advanced method of separating and identifying blood proteins. In 1960 he returned to Wisconsin to teach, and in 1988 he joined the faculty at the University of North Carolina in Chapel Hill.
While researching gene therapy as a method for treating hereditary diseases in the 1980s, Smithies uncovered the work that Evans had been doing on the embryonic stem cells of mice. Using a sample obtained from Evans, he demonstrated that targeted removal or alteration of genes within the stem cells allowed for the controlled manipulation of the mouse genome. He and Capecchi used that breakthrough to breed mice with specific disease conditions. In 1991 Smithies and his laboratory created a “knockout mouse”—so named because one of its genes had been experimentally replaced or “knocked out”—that accurately modeled human cystic fibrosis.
Smithies was elected to the U.S. National Academy of Sciences in 1971. In addition to the Nobel Prize, Smithies, Capecchi, and Evans won the 2001 Albert Lasker Basic Medical Research Award, and Smithies and Capecchi shared (with Ralph L. Brinster) the 2003 Wolf Prize for Medicine.
Note from Encyclopædia Britannica, https://www.britannica.com/biography/Oliver-Smithies. Accessed May 10, 2017.
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Scope and Content
Class notes and tutorial essays written by Oliver Smithies during his time as a student at Balliol College, University of Oxford; and research notes, student papers, and laboratory notebooks compiled by Smithies throughout his career. The collection includes some of Smithies's research notes related to the discoveries that helped earn him the Nobel Prize in Physiology or Medicine.
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Series Quick Links
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Series 1. Papers, circa 1948-2015
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Series 2. Laboratory notebooks, circa 1948-2010
| Folder 89 |
Laboratory notebook, 1948-1949 (Graduate notebook 1)Institution: Balliol College (University of Oxford). |
| Folder 90 |
Laboratory notebook, 1949 (Graduate notebook 2)Institution: Balliol College (University of Oxford) |
| Folder 91 |
Laboratory notebook, 1949-1950 (Graduate notebook 3)Institution: Balliol College (University of Oxford) |
| Folder 92 |
Laboratory notebook, 1950-1951 (Graduate notebook 4)Institution: Balliol College (University of Oxford) |
| Folder 93 |
Laboratory notebook, 1951 (Thesis)Institution: Balliol College (University of Oxford) |
| Folder 94 |
Laboratory notebook, 1951 (Abstract of Thesis)Institution: Balliol College (University of Oxford) |
| Folder 95 |
Laboratory notebook, 1951-1952 (Postdoc Period #1)Institution: University of Wisconsin--Madison |
| Folder 96 |
Laboratory notebook, 1952 (Postdoc Period #2)Institution: University of Wisconsin--Madison |
| Folder 97 |
Laboratory notebook, 1952-1953 (Postdoc Period #3)Institution: University of Wisconsin--Madison |
| Folder 98 |
Laboratory notebook, 1953 (Postdoc Period #4)Institution: University of Wisconsin--Madison |
| Folder 99 |
Laboratory notebook, 1953 (O.S. Planning Notes) |
| Folder 100 |
Laboratory notebook, 1953 (I-Physical)Institution: University of Toronto |
| Folder 101 |
Laboratory notebook, 1954 (II)Institution: University of Toronto |
| Folder 102 |
Laboratory notebook, 1954 (III)Institution: University of Toronto |
| Folder 103 |
Laboratory notebook, 1954-1955 (IV)Institution: University of Toronto |
| Folder 104 |
Laboratory notebook, 1955 (V)Institution: University of Toronto |
| Folder 105 |
Laboratory notebook, 1955-1956 (VI)Institution: University of Toronto |
| Folder 106 |
Laboratory notebook, 1956 (VII)Institution: University of Toronto Click here for more information. |
| Folder 107 |
Laboratory notebook, 1956 (VIII)Institution: University of Toronto |
| Folder 108 |
Laboratory notebook, 1956 (IX)Institution: University of Toronto |
| Folder 109 |
Laboratory notebook, 1956-1957 (X)Institution: University of Toronto |
| Folder 110 |
Laboratory notebook, 1957 (XI)Institution: University of Toronto |
| Folder 111 |
Laboratory notebook, 1957 (XII)Institution: University of Toronto |
| Folder 112 |
Laboratory notebook, 1957 (XIII)Institution: University of Toronto |
| Folder 113 |
Laboratory notebook, 1957 (XIV)Institution: University of Toronto |
| Folder 114 |
Laboratory notebook, 1957-1958 (XV)Institution: University of Toronto |
| Folder 115 |
Laboratory notebook, 1958 (XVI)Institution: University of Toronto |
| Folder 116 |
Laboratory notebook, 1958 (XVII)Institution: University of Toronto |
| Folder 117 |
Laboratory notebook, 1958 (XVIII)Institution: University of Toronto |
| Folder 118 |
Laboratory notebook, 1958-1959 (XIX) |
| Folder 119 |
Laboratory notebook, 1959 (XX)Institution: University of Wisconsin--Madison |
| Folder 120 |
Laboratory notebook, 1959 (XXI)Institution: University of Wisconsin--Madison |
| Folder 121 |
Laboratory notebook, 1959-1960 (XXII)Institution: University of Wisconsin--Madison |
| Folder 122 |
Laboratory notebook, 1960 (XXIII)Institution: University of Wisconsin--Madison |
| Folder 123 |
Laboratory notebook, 1960 (A) |
| Folder 124 |
Laboratory notebook, 1960 (B) |
| Folder 125 |
Laboratory notebook, 1960 (C) |
| Folder 126 |
Laboratory notebook, 1960-1961 (D)Institution: University of Wisconsin--Madison |
| Folder 127 |
Laboratory notebook, 1961 (E)Institution: University of Wisconsin--Madison |
| Folder 128 |
Laboratory notebook, 1961 (F)Institution: University of Wisconsin--Madison |
| Folder 129 |
Laboratory notebook, 1961 (G)Institution: University of Wisconsin--Madison |
| Folder 130 |
Laboratory notebook, 1961-1962 (H)Institution: University of Wisconsin--Madison |
| Folder 131 |
Laboratory notebook, 1962 (I)Institution: University of Wisconsin--Madison |
| Folder 132 |
Laboratory notebook, 1962-1963 (J)Institution: University of Wisconsin--Madison |
| Folder 133 |
Laboratory notebook, 1962-1963 (K)Institution: University of Wisconsin--Madison |
| Folder 134 |
Laboratory notebook, 1962 (L)Institution: University of Wisconsin--Madison |
| Folder 135 |
Laboratory notebook, 1963 (M)Institution: University of Wisconsin--Madison |
| Folder 136 |
Laboratory notebook, 1963 (N)Institution: University of Wisconsin--Madison |
| Folder 137 |
Laboratory notebook, 1963-1964 (O)Institution: University of Wisconsin--Madison |
| Folder 138 |
Laboratory notebook, 1964 (P)Institution: University of Wisconsin--Madison |
| Folder 139 |
Laboratory notebook, 1964-1965 (Q) |
| Folder 140 |
Laboratory notebook, 1965 (R)Institution: University of Wisconsin--Madison |
| Folder 141 |
Laboratory notebook, 1965-1966 (S)Institution: University of Wisconsin--Madison Institution: University of Wisconsin--Madison |
| Folder 142 |
Laboratory notebook, 1966 (T)Institution: University of Wisconsin--Madison |
| Folder 143 |
Laboratory notebook, 1966-1967 (U)Institution: University of Wisconsin--Madison |
| Folder 144 |
Laboratory notebook, 1967 (V)Institution: University of Wisconsin--Madison |
| Folder 145 |
Laboratory notebook, 1967 (W)Institution: University of Wisconsin--Madison |
| Folder 146 |
Laboratory notebook, 1967-1968 (X)Institution: University of Wisconsin--Madison |
| Folder 147 |
Laboratory notebook, 1968 (Y)Institution: University of Wisconsin--Madison |
| Folder 148 |
Laboratory notebook, 1968-1969 (Z)Institution: University of Wisconsin--Madison |
| Folder 149 |
Laboratory notebook, 1969-1970 (a)Institution: University of Wisconsin--Madison |
| Folder 150 |
Laboratory notebook, 1972 (b)Institution: University of Wisconsin--Madison |
| Folder 151 |
Laboratory notebook, 1972-1973 (c)Institution: University of Wisconsin--Madison |
| Folder 152 |
Laboratory notebook, 1973 (d)Institution: University of Wisconsin--Madison |
| Folder 153 |
Laboratory notebook, 1973 (e)Institution: University of Wisconsin--Madison |
| Folder 154 |
Laboratory notebook, 1973 (f)Institution: University of Wisconsin--Madison |
| Folder 155 |
Laboratory notebook, 1973-1974 (g)Institution: University of Wisconsin--Madison |
| Folder 156 |
Laboratory notebook, 1974 (h)Institution: University of Wisconsin--Madison |
| Folder 157 |
Laboratory notebook, 1974 (i)Institution: University of Wisconsin--Madison |
| Folder 158 |
Laboratory notebook, 1974 (j)Institution: University of Wisconsin--Madison |
| Folder 159 |
Laboratory notebook, 1974-1975 (k)Institution: University of Wisconsin--Madison |
| Folder 160 |
Laboratory notebook, 1975-1976 (l)Institution: University of Wisconsin--Madison |
| Folder 161 |
Laboratory notebook, 1976 (m)Institution: University of Wisconsin--Madison |
| Folder 162 |
Laboratory notebook, 1976 (n) |
| Folder 163 |
Laboratory notebook, 1976-1977 (o) |
| Folder 164 |
Laboratory notebook, 1977 (p)Institution: University of Wisconsin--Madison |
| Folder 165 |
Laboratory notebook, 1977 (q)Institution: University of Wisconsin--Madison |
| Folder 166 |
Laboratory notebook, 1977-1978 (r)Institution: University of Wisconsin--Madison |
| Folder 167 |
Laboratory notebook, 1978 (s)Institution: University of Wisconsin--Madison |
| Folder 168 |
Laboratory notebook, 1978 (t)Institution: University of Wisconsin--Madison |
| Folder 169 |
Laboratory notebook, 1978-1979 (u)Institution: University of Wisconsin--Madison |
| Folder 170 |
Laboratory notebook, 1979 (v)Institution: University of Wisconsin--Madison |
| Folder 171 |
Laboratory notebook, 1979-1980 (w)Institution: University of Wisconsin--Madison |
| Folder 172 |
Laboratory notebook, 1980 (x)Institution: University of Wisconsin--Madison |
| Folder 173 |
Laboratory notebook, 1980 (y)Institution: University of Wisconsin--Madison |
| Folder 174 |
Laboratory notebook, 1980-1981 (z)Institution: University of Wisconsin--Madison |
| Folder 175 |
Laboratory notebook, 1981 (α)Institution: University of Wisconsin--Madison |
| Folder 176 |
Laboratory notebook, 1981-1982 (β)Institution: University of Wisconsin--Madison |
| Folder 177 |
Laboratory notebook, 1982 (γ)Institution: University of Wisconsin--Madison |
| Folder 178 |
Laboratory notebook, 1982 (δ)Institution: University of Wisconsin--Madison |
| Folder 179 |
Laboratory notebook, 1982-1983 (ε)Institution: University of Wisconsin--Madison |
| Folder 180 |
Laboratory notebook, 1983 (ζ)Institution: University of Wisconsin--Madison |
| Folder 181 |
Laboratory notebook, 1983 (η)Institution: University of Wisconsin--Madison |
| Folder 182 |
Laboratory notebook, 1983-1984 (θ)Institution: University of Wisconsin--Madison |
| Folder 183 |
Laboratory notebook, 1984-1985 (ι)Institution: University of Wisconsin--Madison |
| Folder 184 |
Laboratory notebook, 1985 (κ)Includes notes on Nobel prize-winning discovery; Institution: University of Wisconsin--Madison |
| Folder 185 |
Laboratory notebook, 1985-1986 (λ)Institution: University of Wisconsin--Madison |
| Folder 186 |
Laboratory notebook, 1986 (μ)Institution: University of Wisconsin--Madison |
| Folder 187 |
Laboratory notebook, 1986-1987 (ν)Institution: University of Wisconsin--Madison |
| Folder 188 |
Laboratory notebook, 1987-1988 (ο)Institution: University of Wisconsin--Madison |
| Folder 189 |
Laboratory notebook, 1988 (π)Institution: University of Wisconsin--Madison |
| Folder 190 |
Laboratory notebook, 1989 (ρ)Institution: University of North Carolina at Chapel Hill |
| Folder 191 |
Laboratory notebook, 1989 (σ)Institution: University of North Carolina at Chapel Hill |
| Folder 192 |
Laboratory notebook, 1990-1991 (τ)Institution: University of North Carolina at Chapel Hill |
| Folder 193 |
Laboratory notebook, 1991 (υ)Institution: University of North Carolina at Chapel Hill |
| Folder 194 |
Laboratory notebook, 1991-1992 (φ)Institution: University of North Carolina at Chapel Hill |
| Folder 195 |
Laboratory notebook, 1992 (χ)Institution: University of North Carolina at Chapel Hill |
| Folder 196 |
Laboratory notebook, 1992-1993 (ψ)Institution: University of North Carolina at Chapel Hill |
| Folder 197 |
Laboratory notebook, 1993 (ω)Institution: University of North Carolina at Chapel Hill |
| Folder 198 |
Laboratory notebook, 1993 (A')Institution: University of North Carolina at Chapel Hill |
| Folder 199 |
Laboratory notebook, 1994 (B')Institution: University of North Carolina at Chapel Hill |
| Folder 200 |
Laboratory notebook, 1994-1995 (C')Institution: University of North Carolina at Chapel Hill |
| Folder 201 |
Laboratory notebook, 1995 (D')Institution: University of North Carolina at Chapel Hill |
| Folder 202 |
Laboratory notebook, 1995-1996 (E')Institution: University of North Carolina at Chapel Hill |
| Folder 203 |
Laboratory notebook, 1996 (F')Institution: University of North Carolina at Chapel Hill |
| Folder 204 |
Laboratory notebook, 1997-1998 (G')Institution: University of North Carolina at Chapel Hill |
| Folder 205 |
Laboratory notebook, 1998 (H')Institution: University of North Carolina at Chapel Hill |
| Folder 206 |
Laboratory notebook, 1998-1999 (I')Institution: University of North Carolina at Chapel Hill |
| Folder 207 |
Laboratory notebook, 1999-2000 (J')Institution: University of North Carolina at Chapel Hill |
| Folder 208 |
Laboratory notebook, 2000-2001 (K')Institution: University of North Carolina at Chapel Hill |
| Folder 209 |
Laboratory notebook, 2001 (L')Institution: University of North Carolina at Chapel Hill |
| Folder 210 |
Laboratory notebook, 2001-2002 (M')Institution: University of North Carolina at Chapel Hill |
| Folder 211 |
Laboratory notebook, 2002-2003 (N')Institution: University of North Carolina at Chapel Hill |
| Folder 212 |
Laboratory notebook, 2003 (O')Institution: University of North Carolina at Chapel Hill |
| Folder 213 |
Laboratory notebook, 2003-2004 (P')Institution: University of North Carolina at Chapel Hill |
| Folder 214 |
Laboratory notebook, 2004 (Q')Institution: University of North Carolina at Chapel Hill |
| Folder 215 |
Laboratory notebook, 2004-2005 (R')Institution: University of North Carolina at Chapel Hill |
| Folder 216 |
Laboratory notebook, 2005-2006 (S')Institution: University of North Carolina at Chapel Hill |
| Folder 217 |
Laboratory notebook, 2006-2007 (T')Institution: University of North Carolina at Chapel Hill |
| Folder 218 |
Laboratory notebook, 2007-2008 (U')Institution: University of North Carolina at Chapel Hill |
| Folder 219 |
Laboratory notebook, 2008-2009 (V')Institution: University of North Carolina at Chapel Hill |
| Folder 220 |
Laboratory notebook, 2009 (W')Institution: University of North Carolina at Chapel Hill |
| Folder 221 |
Laboratory notebook, 2009-2010 (X')Institution: University of North Carolina at Chapel Hill |
| Folder 222 |
Laboratory notebook, 2010 (Y')Institution: University of North Carolina at Chapel Hill |
| Folder 223 |
Laboratory notebook, 2010 (Z')Institution: University of North Carolina at Chapel Hill |
| Folder 224 |
Laboratory notebook, 1958-1960 (Rh-Hapten) |
| Folder 225 |
Laboratory notebook, 1958-1960 (Photography) |
| Folder 226 |
Laboratory notebook, 1953-1954 (Insulin)Institution: University of Toronto |
| Folder 227 |
Laboratory notebook, 1956-1958 (Collected Data) |
| Folder 228 |
Laboratory notebook, 1956-1958 (Collected Data II) |
| Folder 229 |
Laboratory notebook, 1959 (Unlabelled) |
| Folder 230 |
Laboratory notebook, 1956-1957 (Otto Hiller)Institution: University of Toronto |
| Folder 231 |
Laboratory notebook, 1961 (FP) |
| Folder 232 |
Laboratory notebook, 1970-1971 (Histone I Hemoglobin OS DLB) |
| Folder 233 |
Laboratory notebook, Formulae |
| Folder 234 |
Laboratory notebook, 1971 (Nucleic Acids DI) |
| Folder 235 |
Laboratory notebook, 1971 (Nucleic Acids DII) |
| Folder 236 |
Laboratory notebook, 2006 (ID-Idea Book)Institution: University of North Carolina at Chapel Hill |
| Folder 237 |
Laboratory notebook, 1964-1986 (S. T.)Institution: University of Wisconsin--Madison |
| Folder 238 |
Laboratory notebook, 1971 (Sequences)Institution: University of Wisconsin--Madison |
| Folder 239 |
Laboratory notebook, 1972-1986 (Unlabelled)Institution: University of Wisconsin--Madison |
| Folder 240 |
Laboratory notebook, 1970-1971 (Seq 9)Institution: University of Wisconsin--Madison |
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Series 3. Lecture Recordings, 2007 and 2009 (Addition of July 2019)
Acquisitions Information: RT 20190712.3.
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Items Separated